Topical medications for precancers

Medicated creams and solutions are especially useful in removing both visible and invisible AKs when the lesions are numerous. The patient applies the medication according to a schedule worked out by the physician. The doctor will also regularly check progress. After treatment, some discomfort may result from skin breakdown, but the risk of scarring is minimal.
5-fluorouracil (5-FU) cream or solution, in concentrations from 0.5 to 5 percent, is the most widely used topical treatment for AK. It works well on the face, ears, and neck. Some redness, swelling, and crusting may occur.
Another preparation, imiquimod cream, is used for multiple keratoses. It causes cells to produce interferon, a chemical that destroys cancerous and precancerous cells.
An alternative treatment, a gel combining, hyaluronic acid and the anti-inflammatory drug diclofenac, also may prove effective.